If the sample rate on the interface and the operating system match (see “Sample rate: why it has to match everywhere”) and you’re still getting crackling or dropouts, it’s usually down to the USB connection itself, not a software setting.
Cables and hubs as a source of trouble
A USB cable that’s too long or low-quality, or a passive USB hub between the computer and the interface, is a common and easily overlooked cause. Connect the interface directly to a port on the computer (not through a hub, not through a keyboard docking station) and use as short a cable as possible, ideally the one included or a high-quality one.
USB power-saving mode (mainly Windows)
Windows can put USB controllers into a power-saving mode when idle, which causes brief dropouts with audio interfaces. In Device Manager, under the relevant USB root hub or USB controller, you can disable “Power Management” → “Allow the computer to turn off this device”.